2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-174706
    Human FGF16 mRNA 98%
    Human FGF16 mRNA encodes the human fibroblast growth factor 16 (FGF16) protein, a member of the fibroblast growth factor (FGF) family. FGF16 probably plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. It is also required for normal cardiomyocyte proliferation and heart development.
    Human FGF16 mRNA
  • HY-174829
    7,4'-Dimethoxy-3-hydroxyflavone 13198-99-7 98%
    7,4'-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 μM. 7,4'-Dimethoxy-3-hydroxyflavone inhibits PAR4-mediated human platelet aggregation and PAR4 signaling pathways, including NF-κB, Ca2+/protein kinase C, Akt, ERK and p38. 7,4'-Dimethoxy-3-hydroxyflavone prevents vascular PAR4 expression, endothelial dysfunction and ameliorates oxidative stress in Streptozotocin (STZ) (HY-13753)-induced diabetic mice. 7,4'-Dimethoxy-3-hydroxyflavone prevents thrombosis in mice without affecting bleeding time[1][2].
    7,4'-Dimethoxy-3-hydroxyflavone
  • HY-17503D
    Metoprolol Hydrochloride 56392-18-8 98%
    Metoprolol Hydrochloride is an orally active and selective β1-adrenoceptor antagonist. Metoprolol Hydrochloride exhibits anti-inflammatory, antitumor, and anti-angiogenic properties.
    Metoprolol Hydrochloride
  • HY-17512R
    Losartan (Standard) 114798-26-4 98%
    Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
    Losartan (Standard)
  • HY-175735
    Factor XI-IN-2 2563884-39-7
    Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus.
    Factor XI-IN-2
  • HY-176045
    LC3B ligand 2 98%
    LC3B ligand 2 is a ligand for E3 ubiquitin ligase. LC3B ligand 2 can be connected to the ligand for protein by a linker to form PROTAC PCSK9 autophagic degrader 2 (HY-176043). PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.
    LC3B ligand 2
  • HY-17608R
    Daprodustat (Standard) 960539-70-2 98%
    Daprodustat (Standard) is the analytical standard of Daprodustat. This product is intended for research and analytical applications. Daprodustat (GSK1278863) is an orally active hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor being developed for the treatment of anemia associated with chronic kidney disease.
    Daprodustat (Standard)
  • HY-176233
    Transthyretin-IN-4 2765296-93-1 98%
    Transthyretin-IN-4 (Compound B26) is a bivalent inhibitor of transthyretin (TTR) amyloidosis (bIC50: 0.09 µM, pIC50: 1.4 µM). Transthyretin-IN-4 is used in the study of fatal heart failure with preserved ejection fraction (HFpEF) and fatal arrhythmias.
    Transthyretin-IN-4
  • HY-176408
    PHD2-IN-5 1262131-72-5 98%
    PHD2-IN-5 (compound 22) is a potent PHD2 inhibitor with an IC50 of 0.82 μM. PHD2-IN-5 can be used in the study of renal anemia.
    PHD2-IN-5
  • HY-176895
    L-Dopa precursor-1 2377146-66-0 98%
    L-Dopa precursor-1 (Compound 5a) is the precursor of 18F-L-Dopa. L-Dopa precursor-1 serves as a core basis for radioactive labeling precursors, allowing the introduction of non-metallic radioactive elements through radiolabeling reactions. L-Dopa precursor-1 can be used for the study of RDN surgery for refractory hypertension, chronic kidney disease.
    L-Dopa precursor-1
  • HY-177282
    SST1 receptor antagonist-2 524743-70-2
    SST1 receptor antagonist-2 (Example 2) is a piperazine derivative and a somatostatin receptor 1 (SST1) antagonist. SST1 receptor antagonist-2 can be used in the research of psychiatric diseases, neurodegenerative diseases, tumors, as well as vascular disorders and immunological diseases.
    SST1 receptor antagonist-2
  • HY-177477
    2,5-Epidithia-3,6-dioxopiperazine 21056-79-1
    2,5-Epidithia-3,6-dioxopiperazine (Formula 15) is a derivative of Epidithiodioxopiperazine (ETP). 2,5-Epidithia-3,6-dioxopiperazine improves intracellular penetration and restores the activity of 2-Cys-Prx (especially Peroxiredoxin II (PrxII)) of form simulation in cells. 2,5-Epidithia-3,6-dioxopiperazine inhibits PDGF-induced proliferation and migration in vascular smooth muscle cells while promoting these actions in endothelial cells with VEGF induction. 2,5-Epidithia-3,6-dioxopiperazine effectively inhibits the proliferation and migration and lung metastasis of melanoma cells. 2,5-Epidithia-3,6-dioxopiperazine can be used for vascular diseases such as hypertension, angina pectoris and myocardial infarction research.
    2,5-Epidithia-3,6-dioxopiperazine
  • HY-177977
    4-Hydroxyalprenolol 54175-82-5
    4-Hydroxyalprenolol (Alp2b) is a metabolite of β-receptor blocker Alprenolol (HY-B1517).
    4-Hydroxyalprenolol
  • HY-179017
    FXa-IN-2 1379458-40-8
    FXa-IN-2 (Compound K3) is a reversible FXainhibitor, with an IC50 value of 45.08 μM. FXa-IN-2 can be used in the research of thromboembolic diseases.
    FXa-IN-2
  • HY-179053
    P2Y12/PDE5-IN-1
    P2Y12/PDE5-IN-1 (Compound 10) is a dual-target inhibitor of P2Y12 (IC50 = 0.271 μg/mL) and PDE5 (IC50 = 0.154 μg/mL). P2Y12/PDE5-IN-1 can be used for research on anti-thrombosis and vasodilation.
    P2Y12/PDE5-IN-1
  • HY-179653
    CX3CR1-IN-1 3105117-66-3 98%
    CX3CR1-IN-1 (Compound 24) is a CX3CR1 inhibitor with an IC50 of 9 nM. CX3CR1-IN-1 can be used for the study of cardiovascular diseases.
    CX3CR1-IN-1
  • HY-180217
    WGU55 98%
    WGU55 is a selective and potent reversible type II transmembrane serine protease TMPRSS6 inhibitor with a Ki of 12.15 nM. WGU55 inhibits TMPRSS6 activity with an IC50 of 138 nMin KEK293 cells. WGU55 has a Ki of 3510 nM (SI = 289) against the homologous protease matriptase and a Ki of 5.2 μM against the coagulation key protease Factor Xa. WGU55 can be used for the research of iron overload related diseases, such as hereditary hemochromatosis.
    WGU55
  • HY-180223
    FXIa-IN-17
    FXIa-IN-17 (Compound FE12) is a selective FXIa inhibitor with an IC50 of 4.4 nM. FXIa-IN-17 effectively inhibits thrombus formation.
    FXIa-IN-17
  • HY-180457
    GR 92549 144501-27-9
    GR 92549 is a potent, orally active, and competitive HMG-CoA reductase inhibitor, can be used as a cholesterol lowering agent.
    GR 92549
  • HY-180583
    GRK5-IN-5 3061801-11-1
    GRK5-IN-5 (Compound 4a) is a selective G protein-coupled receptor (GPCR) kinase 5 (GRK5) inhibitor with an IC50 of 0.03 μM. GRK5-IN-5 shows IC50 values of 2.2 and 0.036 μM for GRK2 and GRK6. GRK5-IN-5 has potent anti-myocardial hypertrophy activity and also inhibits the proliferation of non-myocardial cells. GRK5-IN-5 can inhibit the abnormal upregulation of hypertrophy marker genes Nppa and Nppb, thus blocking pathological myocardial remodeling. GRK5-IN-5 can be used for the research of cardiac hypertrophy.
    GRK5-IN-5
Cat. No. Product Name / Synonyms Application Reactivity